Brazilian coach Tite was forced into some delayed changes in the team that will face Uruguay and Cameroon in friendly matches in England after Philippe Coutinho of Barcelona and Marcelo and Casemiro in Real Madrid who got injured.
Tite called Barcelona midfielder Rafinha Alcantara on Monday to replace Casemiro, who suffers from an ankle sprain that would reduce him for several weeks.
He also added Beijing Guoan midfielder Renato Augusto and Juventus, Alex Sandro.
Coutinho's absence was expected after Barca announced on Thursday that he had a problem that would keep him out for two weeks.
Tite hoped to call Marcelo, but Real left-back has not recovered yet a thigh problem suffered two weeks ago at Clasico, which Madrid lost 5-1 of its bitter rivals from Barcelona.
The Brazilian Football Association issued a statement saying that Tite "is waiting to see if it will recover," but after Marcelo's departure from the Real 4-2 victory over Celta Vigo it was decided on the weekend that it would be inappropriate.
Brazil will play Uruguay at Arsenal's Emirates Stadium on Friday before taking Cameroon to Milton Keynes four days later.
It will be the last two games of the year that have recorded four straight friendly wins since leaving the World Cup in Russia in the four-month stage, beat 2-1 from Belgium.
Brazil beat the United States 2-0, El Salvador 5-0, Saudi Arabia 2-0 and Argentina 1-0 in the last four races. The side opens to Copa America next year, which will be hosted from June 14 to July 7.